Créatine Creapure® 150g - Nutripure

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  • Creapure® raw material (100% creatine monohydrate)
  • French artisanal manufacturing
  • Packaging in fully recyclable Kraft Doypack
  • High quality and traceability (tested for impurities)
  • Numerous clinical studies
  • Supports physical performance and promotes muscle gain
Very popular with athletes, creatine promotes performance and muscle strength Voir plus
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Créatine Creapure® 150g - Nutripure

Créatine Creapure® 150g - Nutripure

17,90 €

Créatine Creapure® 150g - Nutripure

17,90 €

➵ Creatine

In times of global shortage, LabZ Nutrition is there to bring you one of the purest creatines on the market!

This creatine is pure, that is to say there is only one ingredient: creatine monohydrate labeled Créapure®. No additives, excipients or anti-caking agents.

The benefits of creatine:

➢ Creatine improves physical abilities in case of successive series of very intense exercises of short duration

➢ Daily consumption of creatine may enhance the effect of strength training on muscle strength in adults over 55 years of age.
Don't wait any longer to benefit from our Creatine!
🏷️ The Creapure® label

➵ Creapure®: let's talk about it

Creapure® is the brand of pure creatine monohydrate produced by AlzChem Trostberg GmbH in Germany. They guarantee high quality products, like Creapure®, which is produced exclusively in their specially designed production facility in Trostberg.

Creapure® is the most studied form of creatine and its safety and effectiveness have been proven. When you buy Creapure® supplements, you can be sure that you are using one of the best and most reliable products on the market.

Creapure® is vegan and exclusively made by chemical synthesis. Raw materials and intermediates are not derived from animal or vegetable products, so there are no traces that may come from animal or vegetable by-products.

➵ Creapure® is subject to strict quality controls

Each batch of Creapure® is tested for purity before leaving the factory. Creapure® is on the Cologne List®. The Cologne List® publishes products whose risk of doping is minimized and which have been tested by a world-renowned laboratory to detect certain doping substances.

There are several ways to make creatine commercially. AlzChem Trostberg GmbH uses a process based on sarcosinate and cyanamide. This method of production is considered the best and safest. In this way, AlzChem Trostberg GmbH minimizes the risk that the creatine produced contains two undesirable by-products: dicyandiamide (DCD) and dihydrotriazine (DHT). Pure creatine should contain no more than a few tens of parts per million (ppm) of DCD and no detectable DHT, which is potentially dangerous. This is the case with Creapure®.

Degradation of creatine during manufacturing or storage can produce creatinine. Levels greater than one percent have been measured in some samples of commercial creatine. In some samples of creatine randomly purchased from the competition, a share greater than one percent was detected. In competing products, creatinine is not dangerous but offers no performance benefit and indicates sloppy manufacturing.

Some commercial creatine tests have reported high levels of other contaminants. In addition to those mentioned above, dietary supplements in general sometimes contain steroids, recreational drugs and other prohibited substances, introduced deliberately or accidentally. It is therefore important to pay attention to the Creapure® logo on the packaging, as it assures you that you are buying the purest and best creatine monohydrate.

➵ Numerous certifications

The production of Creapure® is IFS FOOD certified, a quality standard recognized by the “Global Food Safety Initiative”.

Additionally, Creapure® is produced in compliance with Jewish and Muslim dietary regulations – and is both Kosher and Halal certified.

⚖ Dosage

➵ The recommended dose

Take a daily dose of approximately 3g, ideally after training in combination with carbohydrates and proteins.

Creatine absorption can be enhanced by insulin, so consume creatine with carbohydrates, proteins, or substances that affect insulin. It is therefore more effective after training during your meal.

WARNINGS: Do not exceed the recommended daily dose. Food supplements should not be used as substitutes for a varied diet. A varied and balanced diet and a healthy lifestyle are important. Keep out of reach of children under three years old. Store in a cool, dry place at room temperature.

➵ How many doses are available with the 500g sachet?

According to the recommended dose (3g), this 500g sachet therefore contains 166 doses of 3g (with an additional dose of 2g remaining).

If you wish to take 6g per day then this sachet contains 83 doses (with an additional 2g dose remaining).

🥄 Ingredients

➵ A single and unique ingredient

100% Creatine monohydrate (Créapure®)

Origin of the raw material: Germany

⚛ Science

➵ Creatine: what is it?

Creatine is a natural amino acid derivative: glycine, arginine and methionine. There are creatine reserves mainly in the skeletal muscles (about 95%) as well as in the brain, liver, kidneys and testicles (representing 5% of creatine reserves)

Creatine, a danger for the kidneys ?

Brazilian researchers then studied the subject to prove that creatine supplements were safe for kidney health. The research team conducted a meta-analysis of 290 studies that used creatine supplementation. Their analysis showed no correlation between creatine consumption and impaired kidney function. However, it is true that blood creatinine levels can be high and increased in people who consume this type of supplement. However, this is a false indicator that in no way reflects kidney damage.

Other results showed that there was no indication of kidney damage following creatine supplementation. Similarly, there was no change in the glomerular filtration rate (which helps assess kidney function).

➬ In conclusion, most studies investigating creatine supplementation have shown no negative effects on kidney function related to this supplementation.

Creatine acts on several levels. It makes it possible to increase the concentration of intramuscular creatine phosphate and therefore to provide a larger quantity of ATP during intense and brief physical effort (weight training) when this exceeds the capacities provided by glucose and fatty acids. It also promotes the synthesis of glycogen in the muscle and the secretion of IGF-1 and MGF which are two anabolic hormones.

Increase in muscle mass and sports performance

Several very recent double-blind studies show that creatine increases muscle mass and improves certain aspects of sports performance, particularly those related to physical strength.

A meta-analysis was performed comparing creatine supplementation to placebo on strength performance measured in exercises lasting less than 3 minutes. 53 studies were investigated in which no link to population or supplementation characteristics was shown which proves the effectiveness of creatine regardless of all listed conditions.

A second meta-analysis was carried out to study the effects of creatine supplementation on high-intensity sports performance ( soccer ) according to the type of metabolism used (aerobic, phosphagen, anaerobic). Creatine supplementation has shown positive effects on anaerobic performance tests. The researchers concluded that with a dose of 20 to 30g of creatine per day, we could observe an improvement in physical performance tests related to anaerobic metabolism, in particular anaerobic power in football players.

Benefit against aging

Creatine could play a role in “healthy” aging, particularly that of the brain.

This is a study carried out in animals. Nevertheless, this experiment carried out by German researchers showed that creatine supplementation could increase the healthy life expectancy of a strain of aged mice. A high dose of creatine could protect nerve cells and prevent cell death and toxic excitation phenomena. In this study, creatine supplementation increased the healthy life expectancy of mice by 9%. These same mice also saw their scores on neurobehavioral tests increase. Finally, brain imaging demonstrated that the supplemented mice had fewer pigments associated with aging ( lalipofuscin ).

➵ Role of antioxidant

New results show that creatine would exert an antioxidant role within the muscle. In one study , researchers gave creatine monohydrate to rats and took muscle samples before and after supplementation. The activity of antioxidant enzymes such as superoxide dismutase 1 and 2, catalase or glutathione peroxidase was evaluated. Creatine supplementation would have reduced free radicals by 33 to 41% depending on the muscles, but the enzymes showed no change in their activity. This would mean that creatine alone would act as an antioxidant by directly fighting against the superoxide radical.

Benefits on intellectual performance

A study by Swansea University investigated the taking of creatine supplements in non-meat eaters. Indeed, creatine is a substance that is found mainly in animal products, which is why people following a vegetarian or vegan diet are subject to a greater risk of creatine deficiencies. The study involved 128 young vegetarian and non-vegetarian women who received either a placebo or a creatine supplement (20g/d) for 5 days. These young women then took tests assessing their brain function at the start as well as at the end of the study. The results showed that creatine supplements improved the memory of vegetarians by 40%.

Improvement of osteoarthritis

A Brazilian study was carried out in patients with osteoarthritis of the knee. A creatine supplement was given to two groups of women, a supplemented group and a placebo group. The study revealed that people who received the creatine supplement (20g/d for one week then 5g/d thereafter) saw their joint stiffness decrease and their leg muscle mass increase. Nevertheless, this is one of the first studies to investigate the effects of creatine supplements on osteoarthritis. Scientific hindsight and additional data are still needed to be able to establish a real correlation.

Everything that is expressed here comes from the scientific literature, it is only pure quotation. Under no circumstances is this dietary supplement intended to diagnose, prevent, treat, limit or cure a pathology/disease.

Creatine supply is limited, take advantage now!

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Alexis - Research and Development Engineer at LabZ Nutrition

The demand for creatine was high, so we wanted to respond to it in a strong and efficient way. Naturally, the Creapure® label was our choice to offer the best quality on the market!

There is a lot of scientific data on creatine and Creapure® has many certificates, which greatly influenced our choice for this label.

Creatine is proven with hundreds of studies certifying its beneficial effects on strength, performance and recovery.

This is one of the best investments to make in dietary supplements.

Being also a physical trainer and athlete, I advise my students to consume 3g before and after training during the pre and post-workout meal or in their post-workout shaker.

Tristank le tank

Tristan - B2B Manager at LabZ Nutrition

L’ANSES (agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail) reconnait à la créatine les allégations de santé suivante :

➢ la créatine améliore les capacités physiques en cas de séries successives d’exercices très intenses de courte durée

➢ la consommation quotidienne de créatine peut renforcer l’effet de la pratique de la musculation sur la force musculaire chez les adultes âgés de plus de 55 ans.

D’autre part, de nombreuses études scientifiques ont étudié le rôle de la créatine sur : 

➢ les performances cognitives 

➢ la fatigue mentale

100% Créatine monohydrate (Creapure®)

Origine de la matière première : Allemagne

Conseil d’utilisation

Prendre une dose par jour de 3g, idéalement après l’entraînement en combinaison avec des glucides et des protéines. Dose journalière maximale recommandée : 3g.

L’absorption de créatine peut être améliorée par l’insuline. Consommer de la créatine avec des glucides, des protéines ou des substances qui influent sur l’insuline. Elle est donc plus efficace après l’entraînement pendant votre repas.

Avertissements : Ne pas dépasser la dose journalière recommandée. Les compléments alimentaires ne doivent pas être utilisés comme substituts à une alimentation variée. Une alimentation variée et équilibrée et un mode de vie sain sont importants. Tenir hors de portée des enfants de moins de trois ans. Conserver dans un endroit frais et sec, à température ambiante.


Combien de doses sont disponibles avec le sachet de 500g ?

Selon la dose recommandée (3g), ce sachet de 500g contient donc 166 doses de 3g (avec une dose de 2g supplémentaire restante).

Si vous souhaitez prendre 6g par jour alors ce sachet contient 83 doses (avec une dose de 2g supplémentaire restante). 

La créatine est un dérivé d’acide aminé naturel : glycine, arginine et méthionine. Il est retrouvé des réserves de créatine dans les muscles squelettiques majoritairement (environ 95%) ainsi que dans le cerveau, le foie, les reins et les testicules (représentant 5% des réserves en créatine) [1].

De façon endogène, de la créatine est synthétisée correspondant à une fourchette d’approximativement 1 à 2g par jour. L’alimentation représente un apport avoisinant les 1g par jour [2, 3]. 


Où la trouve-t-on dans l’alimentation ? 

Dans les produits carnés : la consommation de viande (+/- 5g de créatine pour 1kg de viande), de poisson et de produits d’originale animale permet un apport de créatine.

Quelques chiffres : Par exemple, dans la volaille, il y a 4,06g de créatine par kilo (4,06g/kg) ; dans le poisson : 4,46g/kg ; l’agneau : 4,71/kg ; le boeuf : 3,90g/kg et le porc : 3,45g/kg.

La supplémentation, pour les personnes ne consommant pas de produits carnés est une possibilité, pour ne pas dire une nécessité, afin d’avoir un apport adéquat en créatine.


Ses propriétés physiologiques

Rôle principal : La créatinine, et particulièrement la phosphocréatine servira de source d’énergie selon la filière de l’anaérobie alactique, cela permet de développer une grande puissance mais sur un temps très court (15 secondes max) médié par les fibres musculaires de type II.

La créatine permet une meilleure récupération ainsi qu’une plus grande charge de travail et une amélioration de la force. Ceci se traduisant par un entraînement pouvant être plus intensif, et à terme obtenir un meilleur gain musculaire, une meilleure hypertrophie [4 – 20].

La physiologie de la créatine [21, 22]


La synthèse de la créatine (Cr) se fait à un taux d’environ 1 g/jour via un processus inter-organes. 

(1) Dans les reins, à partir de la L-arginine, la glycine amidinotransférase (AGAT) transfère un groupe amidino de la L-arginine à la glycine, ce qui entraîne la formation de L-ornithine et de guanidinoacétate (GAA). Le GAA est ensuite transféré et traité dans le foie. La guanidinoacétate N-méthyltransférase (GAMT) transfère un groupe méthyle du donneur de méthyle S-adénosylméthionine (SAM) au GAA, ce qui entraîne la formation de Cr et de S-adénosylhomocystéine (SAH). La SAH peut ensuite être hydrolysée en homocystéine par la S-adénosylhomocystéine hydrolase (non représentée). (3) Le Cr est libéré du foie dans la circulation, où il est transporté vers divers tissus tels que les muscles squelettiques, le cerveau, les reins et le cœur. (4) L’absorption cellulaire de Cr est médiée par un transporteur de créatine (CRT), ou SLC6A8. Le Cr porte des charges positives et négatives, et est transporté par un transport secondaire actif, entraîné par un gradient généré par la sodium/chlorure-ATPase. Une fois dans la cellule, Cr a une multitude de destins. (5) Le Cr cellulaire peut être transformé en phosphocréatine (PCr) par la créatine kinase mitochondriale (mtCK) qui est couplée à la phosphorylation oxydative (OP) via la chaîne de transport d’électrons (ETC). (6) Le Cr peut être converti en PCr par la créatine kinase cytosolique (Cyt. CK) couplée à la glycolyse. (7) Le pool cellulaire de Cr/PCr est utilisé pour maintenir les rapports adénosine triphosphate (ATP)/adénosine diphosphate (ADP) par la resynthèse de l’ATP ou “tamponnage”. (8) Cyt. CKs situées dans tout le cytosol peuvent utiliser les réserves de PCr à haute énergie pour faire la navette et utiliser l’énergie aux sites de demande d’ATP, ou aux processus dépendants de l’ATP, via les enzymes ATPases. Ces processus comprennent les canaux ioniques utilisant de l’ATP, les récepteurs régulés par l’ATP, les pompes ioniques régulées par l’ATP, les processus contractiles, la motilité cellulaire, la signalisation cellulaire ou le transport des organites. (9) Le Cr et le PCr sont tous deux naturellement métabolisés en créatinine par une réaction non enzymatique et spontanée. La créatinine diffuse librement dans la circulation pour être transportée vers les reins. (10) La créatinine est entièrement excrétée dans l’urine.


 

Créatine et santé des reins : cela fait-il bon ménage ?

Des chercheurs brésiliens [23] ont étudié le sujet pour prouver que les suppléments de créatine étaient sûrs pour la santé des reins. L’équipe de chercheurs a fait une méta-analyse de 290 études ayant fait appel à la supplémentation en créatine. Leur analyse n’a montré aucune corrélation entre la consommation de créatine et l’altération de la fonction rénale. Il est cependant vrai que les taux de créatinine sanguin peuvent être élevés et augmentés chez des personnes consommant ce type de compléments. Néanmoins, il s’agit d’un faux indicateur qui ne reflète en rien un dommage au niveau rénal.

D’autres résultats [24 – 29] ont montré qu’il n’y avait pas d’indication de lésions rénales suite à la supplémentation en créatine. De même, il n’y avait pas de changement dans le taux de filtration glomérulaire (qui permet d’évaluer la fonction rénale). 

➬ En conclusion, la plupart des études étudiant la supplémentation en créatine n’ont démontré aucuns effets négatifs sur la fonction rénale liés à cette supplémentation.


Bibliographie

[1] James B. Walker Creatine: Biosynthesis, Regulation, and Function James B. Walker Alton Meister 01 January 1979


[2] Mesa, J. L., Ruiz, J. R., Gonzalez-Gross, M. M., Gutierrez Sainz, A., Castillo Garzon, M. J., Oral creatine supplementation and skeletal muscle metabolism in physical exercise. Sports Med. 2002, 32, 903-944.


[3] Poortmans, J. R., Rawson, E. S., Burke, L. M., Stear, S. J., Castell, L. M., A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance Part 11. Br. J. Sports Med. 2010, 44, 765-766.

[4] Nunes JP, Ribeiro AS, Schoenfeld BJ, Tomeleri CM, Avelar A, Trindade MC, Nabuco HC, Cavalcante EF, Junior PS, Fernandes RR, Carvalho FO, Cyrino ES. Creatine supplementation elicits greater muscle hypertrophy in upper than lower limbs and trunk in resistance-trained men. Nutr Health. 2017
  
 [5] Antonio, J., Ciccone, V. The effects of pre versus post workout supplementation of creatine monohydrate on body composition and strength. J Int Soc Sports Nutr 10, 36 (2013)
  
 [6] Souza-Junior, T.P., Willardson, J.M., Bloomer, R. et al. Strength and hypertrophy responses to constant and decreasing rest intervals in trained men using creatine supplementation. J Int Soc Sports Nutr 8, 17 (2011)
  
 [7] Hespel P, Op’t Eijnde B, Van Leemputte M, Urso B, Greenhaff PL, Labarque V, Dymarkowski S, Van Hecke P, Richter EA: Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans. J Physiol. 2001, 536: 625-633.
  
 [8] Moretti, I., Ciciliot, S., Dyar, K. et al. MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity. Nat Commun 7, 12397 (2016).
  
 [9] Volek, Jeff S.; Duncan, Noel D.; Mazzetti, Scott A.; Staron, Robert S.; Putukian, Margot; Gómez, Ana L.; Pearson, David R.; Fink, William J.; Kraemer, William J. Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training, Medicine & Science in Sports & Exercise : August 1999 – Volume 31 – Issue 8 – p 1147-1156


 [10] Becque MD, Lochmann JD, Melrose DR: Effects of oral creatine supplementation on muscular strength and body composition. Med Sci Sports Exerc. 2000, 32: 654-658.


 [11] Bemben MG, Bemben DA, Loftiss DD, Knehans AW: Creatine supplementation during resistance training in college football athletes. Med Sci Sports Exerc. 2001, 33: 1667-1673.


  [12] Branch JD, Schwarz WD, Van Lunen B: Effect of creatine supplementation on cycle ergometer exercise in a hyperthermic environment. J Strength Cond Res. 2007, 21: 57-61. 


  [13] Larson-Meyer DE, Hunt GR, Trowbridge CA, Turk JC, Ernest JM, Torman SL, Harbin PA: The effect of creatine supplementation on muscle strength and body composition during off-season training in female soccer players. J Strength Cond Res. 2000, 14: 434-442.


  [14] Vandenberghe K, Goris M, Van Hecke P, Van Leeputte M, Vanderven L, Hespel P: Long-term creatine intake is beneficial to muscle performance during resistance training. J Appl Physiol. 1997, 83: 2055-2063.
  
 [15] Jones AM, Atter T, Georg KP: Oral creatine supplementation improves multiple sprint performance in elite ice-hockey players. J Sports Med Phys Fitness. 1999, 39: 189-196.


  [16] Stone MH, Sanborn K, Smith LL, O’Bryant HS, Hoke T, Utter AC, Johnson RL, Boros R, Hruby J, Pierce KC, Stone ME, Garner B: Effects of in-season (5 weeks) creatine and pyruvate supplementation on anaerobic performance and body composition in American football players. Int J Sport Nutr. 1999, 9: 146-165
  
 [17] Kreider RB, Almada AL, Antonio J, Broeder C, Earnest C, Greenwood M, Incledon T, Kalman DS, Kleiner SM, Leutholtz B, Lowery LM, Mendel R, Stout JR, Willoughby DS, Ziegenfuss TN: Exercise and sport nutrition review: research and recommendations. Sport Nutr Rev J. 2004, 1: 1-44.


  [18] Willoughby DS, Rosene JM: Effects of oral creatine and resistance training on myogenic regulatory factor expression. Med Sci Sports Exerc. 2003, 35: 923-929. 


  [19] Willoughby DS, Rosene JM: Effects of oral creatine and resistance training on myosin heavy chain expression. Med Sci Sports Exerc. 2001, 33: 1674-1681. 


  [20] Lanhers, C., Pereira, B., Naughton, G. et al. Creatine Supplementation and Upper Limb Strength Performance: A Systematic Review and Meta-Analysis. Sports Med 47, 163–173 (2017).

[21] Clarke H, Kim D-H, Meza CA, Ormsbee MJ, Hickner RC. The Evolving Applications of Creatine Supplementation: Could Creatine Improve Vascular Health? Nutrients. 2020; 12(9):2834

[22] Kianoush Kashani, Mitchell H. Rosner and Marlies Ostermann.  Creatinine : From physiology to clinical application European Journal of Internal Medicine. Volume 72, P9-14, February 01, 2020

[23] de Souza E Silva A, Pertille A, Reis Barbosa CG, Aparecida de Oliveira Silva J, de Jesus DV, Ribeiro AGSV, Baganha RJ, de Oliveira JJ. Effects of Creatine Supplementation on Renal Function: A Systematic Review and Meta-Analysis. J Ren Nutr. 2019 Nov;29(6):480-489. 

[24] Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc. 1999 Aug;31(8):1108-10. 

[25] Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sports Exerc. 2000 Feb;32(2):291-6. 

[26] Kreider RB, Kalman DS, Antonio J, Ziegenfuss TN, Wildman R, Collins R, Candow DG, Kleiner SM, Almada AL, Lopez HL. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017 Jun 13;14:18.

[27] Pline KA, Smith CL. The effect of creatine intake on renal function. Ann Pharmacother. 2005 Jun;39(6):1093-6.

[28] Ropero-Miller JD, Paget-Wilkes H, Doering PL, Goldberger BA. Effect of oral creatine supplementation on random urine creatinine, pH, and specific gravity measurements. Clin Chem. 2000 Feb;46(2):295-7. 

[29] Williamson L, New D. How the use of creatine supplements can elevate serum creatinine in the absence of underlying kidney pathology. BMJ Case Rep. 2014 Sep 19;2014:bcr2014204754. 

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Créatine Creapure® 150g - Nutripure

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