EVNol® Suprabio

The label

EVNol® is a range of "vitamin E" based on an extract of crude and virgin palm oil, patented, designed by the Malaysian company ExcelVite, offering a natural complex of tocotrienols (78%) and tocopherols (22% ) with significantly improved bioavailability and bioefficacy compared to similar supplements on the market.

Composition :

EVNol SupraBio® is a product from the EVNol® range. It is mainly composed of a complex of full-spectrum tocotrienols (combination of alpha, beta, gamma and delta-tocotrienols with the highest ratio) and tocopherols extracted from the oil of the fruits of red palm ( Elaeis guineensis ) fresh and pristine. Tocotrienols and tocopherols are the molecules that make up “vitamin E”. Tocotrienols are similar in structure to tocopherols but differ in their side chain unsaturation. Tocotrienols are often referred to as “unsaturated vitamin E” and have been scientifically proven to be more effective 1 (in terms of antioxidant capabilities) with additional biological activities (neuroprotection 2.3 , hepatoprotection 6 , cardioprotection 4.5 ) compared to tocopherols.

EVNol SupraBio® also contains phytosterols, squalene, coenzyme Q10 (CoQ10) and carotenoids (beta-carotenes).

Function :

EVNol SupraBio® is a complex of tocotrienols and tocopherol, two molecules which are generalized under the name of “vitamin E”. This vitamin is known for its powerful antioxidant activity but it has several other functions, in particular thanks to the tocotrienols that compose it. When taken regularly, EVNol SupraBio® has been shown to promote a variety of health benefits, from improving cardiovascular, brain, liver wellness to boosting the immune system.

One of the first functions of EVNol SupraBio® is a neuroprotective function. Indeed, it has been reported that alpha-tocotrienol (and not alpha-tocopherol) is able to prevent glutamate-induced toxicity during stroke as well as the appearance of white matter lesions which is a risk factor for stroke 2 .

EVNol SupraBio® is able to cross the blood-brain barrier and impart its powerful antioxidant effects to the brain and thus support and improve basic cognitive and brain functions.

A second function of EVNol SupraBio® is therefore its role as an antioxidant, particularly at the hepatic level where it helps to reduce the risk of developing hepatic steatosis (associated with hepatic peroxidation which causes acute oxidative stress and therefore increased production free radicals). Tocotrienols are a more potent form of antioxidants and are preferentially distributed and accumulated in the liver, which explains the hepatoprotective function of EVNol SupraBio®. A clinical trial 6 showed the hepatoprotective effects of mixed palm tocotrienols in hypercholesterolemic adults with NAFLD (non-alcoholic fatty liver disease).

EVNol SupraBio® can facilitate liver function and fight related complications such as fatty liver disease.

The third function of EVNol SupraBio® lies in its role as a cardioprotector. Indeed, tocotrienols have been shown to suppress a key enzyme in the synthesis of bad cholesterol in the liver without causing fatigue or long-term muscle weakness unlike drugs prescribed for high cholesterol (statins) 4, 5.7 .

EVNol SupraBio® improves cardiovascular health by lowering cholesterol, triglyceride and cytokine levels (immune system hormones involved in the inflammatory reaction).

The last main function of EVNol SupraBio® is to preserve the beauty of skin and hair. Indeed, oxidative stress negatively affects the health of the latter. Tocotrienols have 40 to 60 times stronger antioxidant activity than tocopherols and are able to distribute evenly on the surface of the skin and build up there much more efficiently. The polyunsaturated form of tocotrienol allows it to penetrate cell membranes more effectively than tocopherols, which allows it to interact more effectively with free radicals to counter them 1 . A patent has also been filed for a formulation containing EVNol SupraBio® which promotes hair growth and reduces hair loss in mammals 8 .

EVNol SupraBio® promotes skin and hair growth. Research has verified its ability to stimulate hair growth in humans and animals.

Another secondary function, EVNol SupraBio®, with its high content of tocotrienols, can have a favorable impact on the immune response by ensuring that it functions at its maximum, in particular to fight against certain toxins such as tetanus 9 . Finally, the high beta-carotene content in EVNol SupraBio® helps support vision through its conversion into retinal (one of the forms of vitamin A).

How is EVNol SupraBio® different from others? :

The tocotrienols of EVNol SupraBio® come from crude and virgin palm oil (palm fruit) which is the most abundant natural source of tocotrienols (78% compared to 70% for PFAD (palm fatty acid distillate). ) and 50% for rice which are other commercial sources). In addition, this source of tocotrienols offers a full spectrum with the 4 isoforms of tocotrienols (which is not the case with annatto seeds, another commercial source, which, although they contain 100% tocotrienols, are only composed delta and gamma-tocotrienol forms).

The extraction technique used by EVNol SupraBio® which consists of an “ultra-high vacuum” at extremely low temperatures is protected by a US patent. Two other patents have been filed, one for the specific process for isolating alpha-tocotrienol and the other for a process for improving this extraction.

EVNol SupraBio® offers the highest percentage of alpha-tocotrienol (most neuroprotective isoform) and gamma-tocotrienol (most cardioprotective isoform) of all commercial tocotrienol products.

Oral bioavailability of tocotrienols has been reported to be low and erratic with absorption ranging from 8.5 to 27.7% (depending on isoform). Vitamin E is fat-soluble and its absorption is therefore highly dependent on the type and amount of lipids (dietary fats) consumed as well as the processes of bile secretion and emulsification in the intestines. EVNol SupraBio® together with the pharmaceutical company Hovid Berhad have developed a patented self-emulsifying delivery system (SEDS) for tocotrienol that provides improved absorption for each isoform by up to 300% compared to a regular tocotrienol extract. The principle is simple, this patented system is a mixture of oil and food emulsifiers which automatically emulsifies in the gastrointestinal tract. This created emulsion then undergoes lipolysis to form particles of the ideal size for optimal and maximized absorption without the need for additional intake or release of dietary fats during bile secretion. A clinical study 10 has moreover demonstrated that the EVNol SupraBio® system makes it possible to obtain a faster, higher rate of absorption of all the isoforms of tocotrienols compared to an ordinary system.

In addition, this improvement and maximization of the absorption of tocotrienols makes it possible to reach a therapeutic plasma level (allowing to achieve the desired health benefits) at a lower dose of supplementation. Indeed, in a recent and first study 11 on the distribution of tocotrienols in human tissues, published in the Journal of Nutrition , it was shown that tocotrienols from the EVNol SupraBio® system are significantly and efficiently absorbed and deposited in the vital organs such as the brain, liver, heart, skin and fatty tissue.

With 15 published human clinical studies and 8 ongoing human clinical trials, including some in neuroprotection funded by the NIH, EVNol SupraBio® is the most clinically studied tocotrienol supplement on the market.

What the EVNol SupraBio® label guarantees:

Clinical research and quality of ingredients:
  • A contribution of the 4 isoforms of tocotrienols ( alpha, beta, gamma and delta-tocotrienol),
  • Achieved health effects (provided tocotrienols in vital organs) with a lower daily dose,
  • A tocotrienols/tocopherols ratio of 78% to 22%,
  • Efficacy demonstrated in numerous large-scale, randomized and controlled clinical trials worldwide (15 human clinical studies published and 8 clinical trials in progress),
  • Tolerance in humans proven in numerous clinical trials (no adverse effects declared for a daily dosage of up to 400mg for a period of up to 2 years).
  • An extraction carried out by a patented process (3 different patents) which preserves the integrity of all the other phytonutrients naturally present in the fruits of the palm tree,
  • Up to 300% improved bioavailability and maximized bioefficacy of tocotrienols thanks to a patented formulation.
Accreditation and Certification:
  • Safety examined by a group of experts ( GRAS certification without an objection letter from the FDA),
  • An ExcelVite company, the only producer of GMP and ISO certified tocotrienols in the world,
  • 100% non-GMO, soy-free, kosher and halal ingredients extracted from sustainably sourced Malaysian raw palm oil,
  • An ExcelVite lab that holds 17025 International Organization for Standardization/International Electrotechnical Commission (ISO/ISE) accreditations (reflecting its high quality),
  • Manufacturing facilities regularly inspected by the US FDA and active participation in the Roundtable on Sustainable Palm Oil (RSPO).

References :

  1. Serbinova, E., et al. (1991). Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radical Biology & medicine , 10, 263-275. PDF
  2. CK Sen. (2006). Alpha-tocotrienol: A Potent Neuroprotective Natural Vitamin E. Medical Tribune, 15-31.
  3. Gopalan, Y., et al. (2014). Clinical Investigation of the Protective Effects of Palm Vitamin E Tocotrienols on Brain White Matter Lesion. Stroke , 45(5), 1422-8. PDF
  4. Pearce, BC., et.al. (1994). Inhibitors of cholesterol biosynthesis. Hypocholesterolemic and antioxidant activities of benzopyran and tetrahydronaphthalene analogs of the tocotrienols. Journal of Medicinal Chemistry, 37, 526–541 . PDF
  5. Pearce, BC., et.al. (1992). Hypocholesterolemic activity of synthetic and natural tocotrienols. Journal of Medicinal Chemistry , 35, 3595–3606. PDF
  6. Magosso, E., et al . (2013). Tocotrienols for normalization of hepatic echogenic response in nonalcoholic fatty liver: a randomized placebo-controlled clinical trial. Nutr J, 12, 166 . PDF
  7. Watson, RR, et.al. (2008). Tocotrienols: Vitamin E Beyond Tocopherols. USA. CRCPress. 269-270.
  8. Beoy, LA., et al. (2010). Effects of tocotrienol supplementation on hair growth in human volunteers. Too Life Sci Res, (2), 91-9. PDF
  9. Mahalingham, D., et al . (2011). Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers. Eur J Clin Nutr. 65(1), 63-9. PDF
  10. Yap, SP., et al. (2004). Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations. Int J Pharmaceuticals, 281, 67-78. PDF
  11. Patel, V., et al . (2012). Oral Tocotrienols are Transported to Human Tissues and Delay the Progression of the Model for End-Stage Liver Disease Score in Patients. The Journal of Nutrition, 142(3), 513-9. PDF