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Folate is normally found in a wide variety of foods and is commonly consumed through a diet of leafy green vegetables, sprouts, fruits, brewer's yeast, and animal products such as milk and dairy products, egg yolk and liver.
Unfortunately, folate in food is unstable and susceptible to oxidation; they rapidly lose potency during food processing, manufacturing and storage and have 25-50% bioavailability, depending on the type of food. Fresh leafy greens stored at room temperature can lose up to 70% of their folate activity in three days and a process of cooking in water can increase the loss to 95%.
Humans cannot synthesize folate, and due to its water-soluble nature, the body stores folate to a limited extent. For this reason, folate is a dietary requirement and must be consumed through food. Whether we ingest foods containing natural or synthetic folates, they are metabolized to 5-methyltetrahydrofolate, which is considered the biologically active form of the B vitamin folic acid.
Humans need to maintain adequate dietary folate intake at different stages of their lives, especially during pre-conception and pregnancy.
➻ Folate contributes to the growth of tissues maternal during pregnancy➻ Folate contributes to the synthesis of amino acids➻ Folate contributes to the normal formation of blood➻ Folate contributes to the normal metabolism of t15>homocysteine➻ Folates contribute to normal psychological functions➻ Folates contribute to the normal functioning of the immune system➻ Folates contribute to reduce
The terms 'folate' and 'folic acid', also known as vitamin B9, are often used interchangeably to indicate a group of water-soluble B vitamins.
In fact, there are differences in the forms:
The term Folic Acid belongs to the 2nd generation which appeared in 1941, Folic acid n has no coenzyme activity and must be reduced to the metabolically active form inside the cell, through a series of biochemical steps before it can be used by the body's cells in vital metabolic pathways such as DNA production, cell reproduction and homocysteine metabolism.
Quatrefolic® represents the fourth generation folate with long-lasting stability and particularly high water solubility , improved bioavailability and well-established safety. This makes it a much more easily absorbed form by the human body.
The inability of some of the world's population to assimilate and metabolize folic acid from food or supplements may endanger their health and increase the risk of health problems. The biologically active form 5-methylfolate, such as Quatrefolic®, is widely recommended as it effectively normalizes the folate status of everyone who consumes it.
Another advantage is that Quatrefolic® passes the gastric barrier and is absorbed primarily in the small intestine by a carrier-mediated mechanism. The transporter is not saturated, allowing Quatrefolic® to ensure higher absorption of folate
Folate deficiency is l one of the most common vitamin deficiencies and the consumption of folate-rich foods may not provide the recommended daily dose, hence the need for supplementation.
Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate and is structurally analogous to the reduced, active form of the acid folic.
Developed by Gnosis S. p A, it represents the fourth generation folate offering greater stability, greater water solubility and multi-ingredient formulation flexibility compared to the calcium salt 5-Methyltetrahydrofolate ensuring improved bioavailability.
"Quatrefolic® has been rigorously tested for security and consistency. It is manufactured under strict quality control procedures allowing Gnosis to promote the product for application in a variety of conventional foods, beverages and supplements. "
Symptoms of Folate deficiency:
• Weakness
• Irritability
• Lack of energy
• Loss of appetite
• Paleness
• Sore red tongue
• Mild mental symptoms, such as forgetfulness and confusion
• Diarrhea
Folate and Pregnancy:
Folate demand increases when human cell growth is very active, such as during pregnancy. Studies have found that low dietary folate intake increases the risk of delivering a child with several types of birth defects, especially neural tube defects (NTDs), and can lead to poor fetal or newborn growth. placenta.
The periconceptional and first period after conception are particularly important for folate supplementation, especially because a woman often does not know she is pregnant.
It is recommended that for all women, folate levels be elevated for at least one month before possible conception and continue at this level for the first three months of pregnancy.
It is one of the essential supplements during the periconceptional period and the first period of pregnancy!
1 Vegan Capsule:
|
Folate (as Quatrefolic® -5-methyltetrahydrofolic acid equivalent to 1.6 mg -5-methyltetrahydrofolic acid, glucosamine salt) 800 mcg DFE |
170% | |
Other Ingredients: Brown Rice Flour, Hypromellose (Vegetable Capsule), Magnesium Stearate.
Quatrefolic® is a registered trademark of Gnosis S. p AT Company.
Advice for use: Take 1 tablet per day with a meal
Warnings: Food supplements should not replace a diet varied and balanced. A healthy lifestyle is important. In people who have had a myocardial infarction, heavy consumption is not recommended. Do not exceed the recommended dose. Keep out of reach of children.
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